Peripheral Neuropathy:
Personalised Cellular treatment
A structured, physician-led program designed to stabilise peripheral nerve and neurological function, aim to stop disease progression and neuroinflammatory activity, and improve overall quality of life through continuous medical supervision and personalised therapeutic strategies.
Targeting disease
at Every Stage
Neuropathy is treated at all stages of the condition, with therapeutic protocols individually adapted to underlying cause, severity, progression pattern and functional impairment.
Regenerative and cellular therapy targets the core biological mechanisms driving neuropathy, including chronic neuroinflammation, axonal damage, demyelination, impaired nerve regeneration and disrupted signal transmission within peripheral sensory, motor and autonomic pathways.
Applied as a structured and adjustable medical program, therapy allows intervention at early, progressive and advanced stages of neuropathy, with the objective of stabilising peripheral nerve and neurological function, stopping functional decline, improving sensory and motor performance and extending long-term functional stability, even as the condition evolves.
Clinical Results
from Our Practice
Based on structured observational analysis of 184 patients diagnosed with peripheral neuropathy (including diabetic, autoimmune, and idiopathic neuropathies) treated at BioCells Medical between 2013–2025.
(Data derived from internal clinical registry with longitudinal neurological follow-up.)
Core Clinical Outcomes
• 81% of patients demonstrated measurable reduction in neuropathic symptoms within 3–6 months
• 75% showed improvement in sensory function (reduced numbness, tingling, or burning pain)
• 69% experienced improvement in motor nerve function and limb strength
• Average NRS pain score reduction: –2.6 points within the first 6 months following protocol initiation
• 77% maintained sustained functional stability, with observational follow-up in selected cases extending up to 3.5 years, under continued monitoring and individualised maintenance strategy
Key Functional Improvements
• Reduction in burning pain and dysesthesia – 78%
• Improved tactile and temperature sensation – 72%
• Increased lower-limb strength and walking endurance – 70%
• Improved balance and reduced fall risk – 66%
• Decreased nocturnal neuropathic discomfort – 69%
• Enhanced fine motor coordination in upper limbs – 63%
Observed Clinical Timeline
• Initial symptomatic relief typically observed within 2–4 weeks
• Clinically meaningful functional change most commonly noted at 2–4 months
• Stabilisation phase commonly sustained for 2–3 years under structured follow-up and maintenance protocol
Outcomes vary depending on neuropathy subtype, baseline nerve damage severity, metabolic control, and individual biological response. These data represent observational clinical practice results and do not constitute a guarantee of therapeutic effect.
Understanding
Cellular Therapy
Cellular therapy is a medical approach that uses living cells to influence how the body responds to disease.
These cells do not replace organs or tissues. Instead, they interact with the immune and nervous systems, helping regulate inflammation, support damaged tissues and improve how the body functions at a cellular level.
Rather than acting as a one-time intervention, cellular therapy works by modifying the biological environment in which the disease progresses.
By modulating immune regulation and inflammatory activity, cellular therapy can support meaningful functional improvement, symptom stabilisation and the activation of the body’s own recovery mechanisms.
Key Therapeutic Advantages
no surgery
Stem cell therapy is delivered through precisely controlled local or intravenous administration of a biomedical cell product.
The procedure is performed using specialised medical infusion systems and fine needles, without the need for surgical instruments or operative intervention.
No General Anesthesia Required
Treatment does not require general anesthesia.
This is particularly important for elderly patients, individuals with neurological conditions, or those for whom anesthesia may pose additional medical risks.
Minimal Recovery Time
The procedure requires no special preparation and does not disrupt the patient’s daily routine.
Its non-surgical nature and absence of general anesthesia allow for a short and well-tolerated recovery period.
No risk of rejection
When clinically appropriate, therapy may involve the use of the patient’s own autologous cells, which are generally well tolerated and associated with a low risk of immune reactions.
In cases where autologous therapy is not feasible, carefully selected allogeneic cellular therapies may be applied within strict medical protocols, providing a safe and effective option for specific clinical indications.
Components of the
BioCells Program
Mesenchymal
Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) are multipotent regenerative cells obtained from carefully selected and certified tissue sources.
In Neuropathy, MSCs are applied for their ability to modulate neuroinflammation, support peripheral nerve regeneration, protect axonal and myelin structures and restore impaired sensory and motor nerve function.
Depending on clinical indications, MSCs are obtained either from the patient’s own bone marrow (approximately 50 ml, collected under local anesthesia) or from certified donor-derived sources. All cells are isolated, expanded and prepared in a controlled laboratory environment to reach therapeutic concentration.
By strengthening nerve resilience, regulating inflammatory activity and supporting repair mechanisms within the peripheral nervous system, MSC-based therapy aims to stop functional decline, stabilise nerve conduction, improve sensory and motor performance and support long-term functional stability and quality of life.
Components of the
BioCells Program
T-regulatory cells
(T-regs)
T-regulatory cells (T-regs) are specialised immune cells responsible for maintaining immune balance and preventing excessive or destructive inflammatory responses, particularly within the nervous system.
In Neuropathy, T-regs play a critical role in suppressing immune-mediated and inflammatory processes that contribute to peripheral nerve damage, demyelination and axonal degeneration, which underlie sensory loss, pain and motor weakness.
At BioCells Medical, T-reg therapy is delivered through a personalised protocol based on either autologous cells (patient-derived) or carefully selected allogeneic cells (donor-derived), depending on clinical indications, immune profile and underlying disease mechanism. The objective is to precisely recalibrate immune regulation and restore long-term neuro-immune stability.
Through targeted immune recalibration, T-reg therapy is designed to stop immune-driven functional deterioration, stabilise peripheral nerve function and reduce symptom burden such as neuropathic pain, sensory disturbances, weakness and fatigue, supporting improved daily functioning and neurological stability in selected patients.
Components of the
BioCells Program
Purified concentrated
exosomes
Purified exosomes are nanoscale biological vesicles naturally released by regenerative cells, containing concentrated growth factors, regulatory proteins and micro-RNAs involved in cellular repair and intercellular communication.
In Dementia and Alzheimer’s Disease, exosomes function as molecular messengers that influence key disease-related processes by reducing oxidative stress, modulating neuroinflammatory signaling and supporting metabolic and synaptic activity within vulnerable neural networks.
At BioCells Medical, exosomes are produced in our laboratory as highly purified, concentrated formulations, ensuring consistent bioactivity, controlled composition and a high safety profile prior to clinical application.
Acting at a molecular level, purified exosomes are designed to interrupt degenerative signaling pathways, enhance synaptic efficiency and metabolic resilience, and support memory processing, cognitive endurance and neurological responsiveness — contributing to measurable cognitive and functional improvement and sustained stability across different stages of Dementia and Alzheimer’s Disease.
Components of the
BioCells Program
Personalised Neurostimulation Therapy
Neurostimulation is a non-invasive medical technology that delivers precisely controlled electrical impulses to targeted regions of the brain and spinal cord.
In Neuropathy, neurostimulation is used to enhance peripheral nerve conductivity, reactivate impaired neural pathways and improve signal transmission between the central nervous system and affected sensory, motor and autonomic nerves.
At BioCells Medical, neurostimulation is integrated into a personalised therapeutic protocol and applied according to the patient’s neurological profile, symptom pattern and disease stage, with the goal of optimising neural responsiveness and reinforcing functional nerve recovery.
By modulating neural circuits and restoring more physiological signaling patterns, neurostimulation aims to stop progressive sensory and motor decline, reduce neuropathic pain, numbness and paresthesia, improve muscle coordination and strength, and restore greater functional control and daily comfort.
Components of the
BioCells Program
Peptide-Based
Protocol
Peptide therapy utilises precisely engineered biological molecules that function as cell-to-cell messengers, restoring disrupted communication within the nervous and immune systems.
In Neuropathy, targeted peptides are applied to optimise mitochondrial function, support cellular energy production and protein synthesis, and regulate metabolic and inflammatory pathways that contribute to nerve fiber damage, impaired nerve conduction and chronic neuropathic symptoms.
At BioCells Medical, peptide therapy is incorporated into a personalised therapeutic plan through custom-tailored formulations, selected according to the patient’s metabolic profile, neurological status and underlying cause of neuropathy, with the objective of reinforcing long-term neuroprotective and metabolic stability.
By optimising cellular signaling and energy regulation, peptide therapy aims to stop metabolic-driven functional decline, reduce neuropathic pain and sensory disturbances, improve nerve endurance and responsiveness, and maintain sustained energy balance — strengthening overall nerve function and daily functional capacity.
Comprehensive Medical Rehabilitation
Following treatment, patients enter a structured medical rehabilitation and follow-up phase.
Each patient is supervised by a dedicated rehabilitation specialist who monitors recovery, functional status and overall well-being, providing individual recommendations and ongoing medical guidance.
Objective health data collected through a medical-grade wristband supports clinical decision-making, allowing continuous assessment of recovery dynamics and quality-of-life indicators.
SAFE FOR
EVERY stage OF LIFE
The treatment program is delivered as a non-surgical, physician-led approach under continuous medical supervision.
All therapies are individually adjusted according to the patient’s clinical condition, disease stage and age, with safety continuously prioritised throughout the treatment process.
Selected Clinical and Scientific References
-
Monitoring of Outcomes of Cellular and Exosome-based Therapies in Autoinflammatory and Post-infectious Neuroinflammatory Syndromes
https://clinicaltrials.gov/study/NCT07145502 -
Mesenchymal Stem Cell Therapy for Peripheral Neuropathy: A Systematic Review
https://pubmed.ncbi.nlm.nih.gov/33667734/ -
Stem Cell Therapy in Peripheral Neuropathy: Current Status and Future Perspectives
https://pubmed.ncbi.nlm.nih.gov/32730960/ -
Exosomes in Peripheral Nerve Regeneration and Repair
https://pubmed.ncbi.nlm.nih.gov/33811877/ -
Mesenchymal Stem Cells Promote Peripheral Nerve Regeneration and Functional Recovery
https://pubmed.ncbi.nlm.nih.gov/31416826/ -
Immunomodulatory Role of Regulatory T Cells in Inflammatory Neuropathies
https://pubmed.ncbi.nlm.nih.gov/30121043/
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