Parkinsonism — reduced rigidity, improved walking and clearer speech

Clinical Case Observation: Parkinsonism

Patient: Franco Bonifazi, 81 years | Italy

Patient Background

Franco Bonifazi, an 81-year-old man from Italy, was diagnosed with parkinsonism. By early 2025, his condition was associated with pronounced motor rigidity, balance instability, reduced mobility, and emerging cognitive decline. These symptoms significantly affected daily functioning, gait safety, and overall independence.

Clinical Approach at BioCells Medical

In March 2025, Franco began a personalised allogeneic regenerative medicine programme at BioCells Medical. The treatment strategy was designed based on his neurological presentation, functional limitations, and age-related considerations, with the goal of supporting motor control, cognitive clarity, and overall neurological stability.

The initial treatment cycle included:

• Placenta-derived mesenchymal stem cells (MSCs) and MSC-derived exosomes,

• T-regulatory cells derived from cord blood,

• Combined intravenous and intranasal administration over two treatment days,

• Two sessions of Electro-Neuro Therapy (ENT),

• A personalised exercise programme developed and supervised by a rehabilitation specialist.

Following the first treatment cycle, early functional changes were observed, including reduced rigidity, increased walking capacity, and improved cognitive responsiveness.

In May 2025, a second treatment cycle was conducted. The protocol utilised the same cellular components and incorporated intrathecal administration with a moderately adjusted cell dose to further support neurological pathways.

Post-Treatment Observations

After completion of the second treatment cycle, Franco’s family reported continued and more pronounced functional changes, including:

• noticeably clearer, faster, and more coherent speech,

• sustained improvements in motor capacity,

• further enhancement of cognitive function and responsiveness.

Given the persistence of balance-related challenges inherent to parkinsonism, the rehabilitation programme was refined after the second cycle to place additional emphasis on gait control, postural stability, and fall prevention.

Follow-Up and Ongoing Monitoring

Franco remains under ongoing medical observation. Functional improvements have been sustained, and his rehabilitation plan continues to be adjusted in line with clinical dynamics and daily performance. Consideration of further treatment cycles remains dependent on neurological evolution and family-defined goals.

Clinical Context

This clinical case demonstrates how a multimodal, personalised regenerative medicine approach, integrated with neurostimulation and rehabilitation, may support motor and cognitive function in patients with parkinsonism. At BioCells Medical, each programme is individually designed and continuously adapted, with close medical oversight throughout the treatment and follow-up phases.

Medical Consultation

Patients and families affected by Parkinson’s disease or atypical parkinsonism who are seeking professional medical guidance may request a free medical consultation with the BioCells Medical team.

Each case is assessed individually to determine the most appropriate, personalised medical strategy.